First off, let me start by just welcoming you to the Core Electronics forum. It’s great to see you here.
Secondly, there are definitely some ways to minimise the rate of ghosting on e-ink screens, but it typically involves minimising what parts of the screen are actually being updated. In my own projects with e-ink screens, I tend to send two images to the display for every partial update: a white rectangle located at the coordinates to be refreshed and then the updated element over top of it. I find that this reduces the ghosting image beneath the screen.
To give you more helpful suggestions, I would need to know: