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There is definitely a good chance that it’s possible, but as @James46717 mentioned you will need something to interpret the UART signal into a digestible input for HA.
We haven’t had a chance to see if it will work or not, and there is limited info available for doing so online. I would say your best bet will be to use an LLM such as chatgpt and run some tests with it.
If your question is whether it will work directly with Home Assistant, then no, it can’t really communicate other than by the GPIO.
However, if you use connect it to a ESP32 GPIO, from the spec sheet: high means presence detected, low mean no detection. This is no different to a PIR sensor. The ESP32 integrates fairly seamlessly with HA using the ESP32Home integration.