Don’t have to disable anything, Nathan. I just connect mine to the blue USB 3 port. Yes, the speed will not be actual USB 3. I am getting about 287 MB/s sequential write speed for the internal speed test compared to about 30 MB/s for Samsung Evo UHS1 128 GB Micro SD.
For a real world scenario, I was able to transfer 7.1 GB (several files not a single file) from my external HDD (USB 3 connected through a USB 3 powered hub) to my RPi SSD in 90 seconds. For me for a SBC, that is good enough.
